The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.
Identifieur interne : 000229 ( Main/Exploration ); précédent : 000228; suivant : 000230The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.
Auteurs : Natalie E. Hofmann [Suisse] ; Stephan Karl [Australie] ; Rahel Wampfler [Suisse] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Albina Teliki [Papouasie-Nouvelle-Guinée] ; Jonah Iga [Papouasie-Nouvelle-Guinée] ; Andreea Waltmann [Australie] ; Inoni Betuela [Papouasie-Nouvelle-Guinée] ; Ingrid Felger [Suisse] ; Leanne J. Robinson [Australie] ; Ivo Mueller [Australie]Source :
- eLife [ 2050-084X ] ; 2017.
Abstract
The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.
DOI: 10.7554/eLife.23708
PubMed: 28862132
Affiliations:
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Hofmann</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Karl, Stephan" sort="Karl, Stephan" uniqKey="Karl S" first="Stephan" last="Karl">Stephan Karl</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Wampfler, Rahel" sort="Wampfler, Rahel" uniqKey="Wampfler R" first="Rahel" last="Wampfler">Rahel Wampfler</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation></author><author><name sortKey="Teliki, Albina" sort="Teliki, Albina" uniqKey="Teliki A" first="Albina" last="Teliki">Albina Teliki</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation></author><author><name sortKey="Iga, Jonah" sort="Iga, Jonah" uniqKey="Iga J" first="Jonah" last="Iga">Jonah Iga</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation></author><author><name sortKey="Waltmann, Andreea" sort="Waltmann, Andreea" uniqKey="Waltmann A" first="Andreea" last="Waltmann">Andreea Waltmann</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Betuela, Inoni" sort="Betuela, Inoni" uniqKey="Betuela I" first="Inoni" last="Betuela">Inoni Betuela</name><affiliation wicri:level="1"><nlm:affiliation>Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.</nlm:affiliation><country xml:lang="fr">Papouasie-Nouvelle-Guinée</country><wicri:regionArea>Papua New Guinea Institute of Medical Research, Goroka</wicri:regionArea><wicri:noRegion>Goroka</wicri:noRegion></affiliation></author><author><name sortKey="Felger, Ingrid" sort="Felger, Ingrid" uniqKey="Felger I" first="Ingrid" last="Felger">Ingrid Felger</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Leanne J" sort="Robinson, Leanne J" uniqKey="Robinson L" first="Leanne J" last="Robinson">Leanne J. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Papouasie-Nouvelle-Guinée</li><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Hofmann, Natalie E" sort="Hofmann, Natalie E" uniqKey="Hofmann N" first="Natalie E" last="Hofmann">Natalie E. Hofmann</name></noRegion><name sortKey="Felger, Ingrid" sort="Felger, Ingrid" uniqKey="Felger I" first="Ingrid" last="Felger">Ingrid Felger</name><name sortKey="Wampfler, Rahel" sort="Wampfler, Rahel" uniqKey="Wampfler R" first="Rahel" last="Wampfler">Rahel Wampfler</name></country><country name="Australie"><noRegion><name sortKey="Karl, Stephan" sort="Karl, Stephan" uniqKey="Karl S" first="Stephan" last="Karl">Stephan Karl</name></noRegion><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><name sortKey="Robinson, Leanne J" sort="Robinson, Leanne J" uniqKey="Robinson L" first="Leanne J" last="Robinson">Leanne J. Robinson</name><name sortKey="Waltmann, Andreea" sort="Waltmann, Andreea" uniqKey="Waltmann A" first="Andreea" last="Waltmann">Andreea Waltmann</name></country><country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name></noRegion><name sortKey="Betuela, Inoni" sort="Betuela, Inoni" uniqKey="Betuela I" first="Inoni" last="Betuela">Inoni Betuela</name><name sortKey="Iga, Jonah" sort="Iga, Jonah" uniqKey="Iga J" first="Jonah" last="Iga">Jonah Iga</name><name sortKey="Teliki, Albina" sort="Teliki, Albina" uniqKey="Teliki A" first="Albina" last="Teliki">Albina Teliki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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